Mst1 inhibits autophagy by promoting the interaction between Beclin1 and Bcl-2
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چکیده
منابع مشابه
Mitochondrial BCL-2 inhibits AMBRA1-induced autophagy.
BECLIN 1 is a central player in macroautophagy. AMBRA1, a BECLIN 1-interacting protein, positively regulates the BECLIN 1-dependent programme of autophagy. In this study, we show that AMBRA1 binds preferentially the mitochondrial pool of the antiapoptotic factor BCL-2, and that this interaction is disrupted following autophagy induction. Further, AMBRA1 can compete with both mitochondrial and e...
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The protein kinases Mst1 and Mst2 have tumor suppressor activity, but their mode of regulation is not well established. Mst1 and Mst2 are broadly expressed and may have certain overlapping functions in mammals, as deletions of both Mst1 and Mst2 together are required for tumorigenesis in mouse models [1-3]. These kinases act via a three-component signaling cascade comprising Mst1 and Mst2, the ...
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ژورنال
عنوان ژورنال: Nature Medicine
سال: 2013
ISSN: 1078-8956,1546-170X
DOI: 10.1038/nm.3322